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Hzf-3 expression in the amygdala after establishment of conditioned taste aversion
H Ge1, R Chiesa, S Peña de Ortiz
1Department of Biology, University of Puerto Rico, Río Piedras Campus, Gándara Avenue, Julio García Díaz Building, Room 108, PO Box 23360, San Juan, Puerto Rico, USA.
Abstract:
We studied the regulation of the expression of the inducible orphan nuclear receptor known as HZF-3 (or Nurr1) in acquisition of conditioned taste aversion in rats. Our results show that HZF-3 expression in the lateral/basolateral (LA/BLA) amygdala complex was significantly up-regulated when both the conditioned and the unconditioned stimuli were paired, but not when either of the stimuli was presented alone. Induction in the LA/BLA had a faster onset than induction in the central nucleus of the amygdala. The results implicate HZF-3 in the acquisition of associative aversive experiences.