Related Experiment Videos
Evaluation of glucose-6-phosphate dehydrogenase activity in two different ethnic groups using a kit employing the
George J Reclos1, Kleopatra H Schulpis, Stavroula Gavrili
1R and D Diagnostics Ltd., 41 El. Venizelou Street, 15561 Holargos, Greece. mail@rddiagnostics.com
Aim:
Correct evaluation of Glucose-6-Phosphate Dehydrogenase (G-6-PD) activity of two ethnic groups using a fully quantitative kit with a simultaneous Hemoglobin Normalization (Hb Normalization) procedure.
Design And Methods:
Two groups of mothers and their healthy full term newborns of Greek (n = 1.166) and Albanian (n = 818) origin were tested for their G-6-PD activity employing a direct normalization protocol.
Results:
Greek mothers and newborns showed a higher prevalence for G-6-PD deficiency as compared to those of Albanian origin. Males of G-6-PD deficient mothers confirmed the efficacy of the method.
Conclusion:
A fully quantitative G-6-PD kit employing Hb Normalization is essential for the correct classification of G-6-PD activity, both in male and female subjects.