Application of the principles of evidence-based medicine to laboratory medicine

The principles of evidence-based medicine and the consequent search for robust evidence on outcomes plays a central role in the practice of laboratory medicine. The core of the evidence lies in an explicit recognition of the clinical question(s) that the test result can address. Studies that focus on the relevant patient cohort and clinical setting for the test, and identify the appropriate outcome measure will generate information that can be used to guide use of the test, identify the benefits, and thereby support the case for investment of resources to deliver the service.