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Related Experiment Videos

Cough sensitivity in atopic dermatitis.

R Pecova1, Z Frlickova, J Pec

  • 1Department of Pathophysiology, Jessenius Medical School, Comenius University, 26 Sklabinska Str, 037 52, Martin, Slovak Republic. pecova@jfmed.uniba.sk

Pulmonary Pharmacology & Therapeutics
|July 10, 2003
PubMed
Summary
This summary is machine-generated.

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Patients with atopic dermatitis show significantly increased cough sensitivity to capsaicin (CAPS), even without respiratory symptoms. This heightened cough reflex was not observed in psoriasis patients compared to controls.

Area of Science:

  • Pulmonology
  • Dermatology
  • Clinical Medicine

Background:

  • Atopic dermatitis is a chronic inflammatory skin condition.
  • Cough sensitivity is a measure of the respiratory system's response to irritants.
  • The relationship between atopic dermatitis and respiratory symptoms is not fully understood.

Purpose of the Study:

  • To investigate cough sensitivity to capsaicin (CAPS) in patients with atopic dermatitis (AD) and psoriasis.
  • To compare cough sensitivity in AD patients without clinical respiratory symptoms to healthy controls and psoriasis patients.

Main Methods:

  • Capsaicin (CAPS) cough sensitivity (C2) was measured using the PARI Provocation Test I.
  • Participants inhaled increasing concentrations of CAPS aerosol.
  • Cough sensitivity (C2) was defined as the lowest CAPS concentration evoking two or more coughs.

Related Experiment Videos

Main Results:

  • Cough sensitivity (C2) was significantly increased in atopic dermatitis patients (0.13 µmol/l) compared to healthy controls (4.29 µmol/l) and psoriasis patients (5.51 µmol/l).
  • The difference in cough sensitivity between AD patients and controls was highly significant (p<0.001).
  • No significant change in cough sensitivity was found in psoriasis patients compared to controls.

Conclusions:

  • Atopic dermatitis patients exhibit significantly heightened cough sensitivity, even in the absence of respiratory symptoms.
  • This suggests a potential link between atopic dermatitis and an overactive cough reflex.
  • Psoriasis patients did not show altered cough sensitivity in this study.