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Updated: Jul 11, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Prostate cancer: a dynamic illness with shifting targets
David R Shaffer1, Howard I Scher
1Genitourinary Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
The Lancet. Oncology
|July 10, 2003
Summary
Androgen ablation for advanced prostate cancer is not curative due to resistant cells. Targeted therapies must address prostate cancer
Area of Science:
- Oncology
- Cancer Biology
- Molecular Medicine
Background:
- Androgen ablation therapy (AAT) shows high response rates but fails to cure advanced prostate cancer.
- The emergence of androgen-independent, resistant prostate cancer cells limits AAT efficacy.
- New targeted therapies aim to overcome resistance by inhibiting key growth and survival pathways.
Purpose of the Study:
- To emphasize the dynamic nature of prostate cancer evolution.
- To highlight the need for targeted therapies that address disease progression.
- To improve clinical outcomes by accounting for dynamic molecular determinants of sensitivity and resistance.
Main Methods:
- Review of current understanding of prostate cancer progression and resistance mechanisms.
- Analysis of emerging targeted therapy strategies.
- Conceptual framework for dynamic treatment approaches.
Main Results:
- Prostate cancer is a dynamic disease that evolves during progression.
- Molecular determinants of sensitivity and resistance are state-specific.
- Current targeted therapies require a dynamic approach for maximum efficacy.
Conclusions:
- Effective eradication of resistant prostate cancer requires understanding its dynamic evolution.
- Targeted therapies must be tailored to specific disease states and molecular determinants.
- A dynamic, adaptive treatment strategy is crucial for improving clinical outcomes in advanced prostate cancer.
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