Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ligneous conjunctivitis.

Volker Schuster1, Stefan Seregard

  • 1Department of Pediatrics, Leipzig University Medical School, Leipzig, Germany.

Survey of Ophthalmology
|July 10, 2003
PubMed
Summary
This summary is machine-generated.

Ligneous conjunctivitis involves woody eye lesions due to impaired wound healing and fibrinolysis. This rare condition is linked to plasminogen deficiency, affecting mucosal tissues systemically.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

FAS-controlled T cells drive lymphoproliferation through glycolysis without effector differentiation.

Journal of human immunity·2026
Same author

Increasing Incidence of Posterior Uveal Melanoma in Scandinavia 1960-2022: A Tri-National Study.

American journal of ophthalmology·2025
Same author

Metastatic conjunctival melanoma: a multicentre international study.

The British journal of ophthalmology·2024
Same author

EU HTA Regulation and Joint Clinical Assessment-Threat or Opportunity?

Journal of market access & health policy·2024
Same author

Abnormal biomarkers predict complex FAS or FADD defects missed by exome sequencing.

The Journal of allergy and clinical immunology·2023
Same author

A serum protein signature at the time of Uveal Melanoma diagnosis predicts long-term patient survival.

BMC cancer·2023
Same journal

Trends in pediatric uveitis: A systematic review and meta-epidemiological investigation of geographic, economic, and climate factors.

Survey of ophthalmology·2026
Same journal

Efficacy and safety of different intraocular therapies for non-infectious uveitis: A network meta-analysis.

Survey of ophthalmology·2026
Same journal

Macular telangiectasia masqueraders.

Survey of ophthalmology·2026
Same journal

Utilization of anterior segment optical coherence tomography in childhood glaucoma: A systematic review.

Survey of ophthalmology·2026
Same journal

Peripapillary pachychoroid syndrome: Clinical and imaging features, diagnostic differentiation and therapeutic strategies.

Survey of ophthalmology·2026
Same journal

Prognostic factors and postoperative outcomes in pediatric cataract patients: A systematic review and meta-analysis.

Survey of ophthalmology·2026
See all related articles

Area of Science:

  • Ophthalmology
  • Hematology
  • Genetics

Background:

  • Ligneous conjunctivitis is a rare chronic condition causing woody pseudomembranes on mucous membranes.
  • It indicates a systemic disease affecting wound healing and fibrinolysis.

Observation:

  • Lesions are rich in fibrin(ogen) and form due to impaired plasmin-mediated extracellular fibrinolysis.
  • Systemic plasminogen deficiency is linked to ligneous conjunctivitis in humans and mice.
  • Antifibrinolytic drugs like tranexamic acid can induce ligneous conjunctivitis.

Findings:

  • Histopathology reveals impaired wound healing in mucosal tissues.
  • Genetic factors and plasminogen deficiency are implicated.
  • Associated rare disorders include hydrocephalus and colloid milium.

Related Experiment Videos

Implications:

  • Understanding the role of fibrinolysis is crucial for managing ligneous conjunctivitis.
  • Plasminogen-deficient mice serve as a valuable model for studying this condition.
  • Further research into hemostasis and genetic factors is warranted.