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Updated: Aug 7, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
Effect of maternal antibodies on the infant immune response
1Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Mail Stop BCM-280, Houston, TX 77030, USA. wglezen@bcm.tmc.edu
Abstract:
Transplacentally-acquired antibodies are important for protection of infants in the early months of life. Maternal antibodies may dampen the infant's primary antibody response to infection or immunization. Even without a measurable response to the initial antigen exposure, the infant will usually have evidence of priming at the time of repeat exposure. No evidence for the development of fetal tolerance after immunization during pregnancy has occurred subsequently in infants following active vaccination.
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