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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)
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The impact of maternal infection or immunization on early-onset autoimmune diabetes

Michel Goldman1, Arnaud Marchant

  • 1Laboratory of Experimental Immunology, Université Libre de Bruxelles, 808 Route de Lennik, B-1070, Brussels, Belgium. mgoldman@ulb.ac.be

Vaccine
|July 10, 2003
PubMed

Maternal immune responses exert short and long-term influences on the newborn immune system. The transfer of maternal antibodies helps the newborn controlling infectious agents that are prevalent in the population. Furthermore, recent studies indicate that the fetus is able to mount inflammatory and cytotoxic T lymphocyte responses in the course of maternal infections. Herein, we discuss the relevance of these observations to the possible relation between maternal infection or immunization and childhood-onset autoimmune diabetes.

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