Related Experiment Video

Updated: Sep 23, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

Developmental factors associated with risk for atopic disease: implications for vaccine strategies in early childhood

P G Holt1, J Rowe, R Loh

  • 1Telethon Institute for Child Health Research, and Centre for Child Health Research, The University of Western Australia, P.O. Box 855, Perth,WA 6872, Australia. patrick@ichr.uwa.edu.au

Vaccine
|July 10, 2003
PubMed

Insights

Infant vaccination

Area of Science:

  • Immunology and Allergy Research
  • Pediatric Health Studies

Background:

  • Growing interest in infant vaccination's impact on atopic disease risk.
  • Debate centers on whether infant vaccination stimulates allergic sensitization.
  • Previous findings are speculative, requiring prospective validation.

Purpose of the Study:

  • To explore the converse hypothesis: genetic atopy risk influencing infant vaccination response.
  • To review recent findings on developmental factors, immune competence, and disease risk in infancy.

Main Methods:

  • Review of recent studies on immune competence and infant disease risk.
  • Analysis of developmental factors influencing immune responses.

Main Results:

  • Conflicting findings reported regarding vaccination and allergic sensitization.
  • Emerging evidence suggests genetic predisposition to atopy may affect vaccine response.
  • Developmental factors play a role in infant immune competence and disease susceptibility.

Conclusions:

  • The converse hypothesis warrants further investigation.
  • Genetic factors in atopy may modulate infant responses to vaccination.
  • Understanding infant immune development is crucial for assessing vaccination and disease risks.

Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness, disability,...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...