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Related Experiment Videos

Molecular basis of plasticity in the visual cortex.

Nicoletta Berardi1, Tommaso Pizzorusso, Gian Michele Ratto

  • 1Laboratory of Neurophysiology, Institute of Neuroscience, Pisa, Italy.

Trends in Neurosciences
|July 10, 2003
PubMed
Summary

Sensory experience shapes brain development, particularly in the visual cortex. New research reveals molecular mechanisms of experience-dependent plasticity and the extracellular matrix

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • Sensory experience profoundly influences cortical circuit maturation.
  • Monocular deprivation in the visual cortex demonstrates this developmental plasticity.
  • Molecular mechanisms underlying this plasticity remain incompletely understood.

Purpose of the Study:

  • To elucidate the molecular mechanisms of experience-dependent plasticity in the developing visual cortex.
  • To investigate the role of intercellular and intracellular signaling pathways.
  • To explore the function of the extracellular matrix in adult visual cortex plasticity.

Main Methods:

  • Review of recent findings on molecular mechanisms.
  • Analysis of intercellular communication and intracellular signaling pathways.

Related Experiment Videos

  • Examination of extracellular matrix involvement in plasticity.

    • Main Results:

    • New data illuminate factors in intercellular and intracellular signaling mediating plasticity.
    • Recent findings suggest the extracellular matrix inhibits ocular-dominance plasticity in adults.

    Conclusions:

    • Significant progress is being made in understanding the molecular basis of visual cortex plasticity.
    • The extracellular matrix emerges as a potential regulator of plasticity in the adult brain.