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Contribution of peripheral NMDA receptors in craniofacial muscle nociception and edema formation

Jin Y Ro1

  • 1Department of Oral and Craniofacial Biological Sciences, University of Maryland Baltimore School of Dentistry, 666 W. Baltimore Street, 21201, Baltimore, MD, USA. jyr001@dental.umaryland.edu

Brain Research
|July 10, 2003
PubMed

Insights

Peripheral NMDA receptors are key players in craniofacial muscle pain and inflammation. Blocking these receptors in the masseter muscle significantly reduced pain behaviors and swelling.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Pain Research

Background:

  • Peripheral N-methyl-D-aspartate (NMDA) receptors are implicated in pain signaling.
  • Their specific role in craniofacial muscle nociception and inflammation requires further elucidation.

Purpose of the Study:

  • To investigate the contribution of peripheral NMDA receptors to nociception and inflammation in craniofacial muscles.

Main Methods:

  • Nocifensive paw-shaking behavior was quantified in rats following masseteric injection of mustard oil (MO).
  • The effect of MK-801, an NMDA receptor antagonist, administered locally or systemically, was assessed.
  • Muscle weight difference between injected and contralateral sides was measured to assess inflammation.

Main Results:

  • Local administration of MK-801 into the masseter muscle significantly reduced MO-induced nociceptive behavior.
  • This local effect was more pronounced than systemic administration or administration into a different muscle (biceps).
  • Local MK-801 pretreatment also significantly reduced the inflammatory weight gain of the masseter muscle.

Conclusions:

  • Peripheral NMDA receptors play a significant role in mediating nociception and inflammation in craniofacial muscles.
  • Targeting peripheral NMDA receptors may offer a therapeutic strategy for craniofacial pain and inflammation.

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