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Hepatocellular carcinoma associated with secondary haemochromatosis in non-cirrhotic liver: a case report

Hobyung Chung1, Masatoshi Kudo, Toshihiko Kawasaki

  • 1Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377-2 Ohno-Higashi, 589-8511, Osaka-Sayama, Japan

Hepatology Research : the Official Journal of the Japan Society of Hepatology
|July 10, 2003
PubMed

We describe one case of hepatocellular carcinoma (HCC) arising in secondary haemochromatosis in a non-cirrhotic liver. The patient was a 40-year-old male. He had severe pancytopenia due to myelodysplastic syndrome (MDS) and developed secondary haemochromatosis as a result of a large amount of erythrocyte transfusion. Multiple nodules of the liver appeared about 6 years after the diagnosis of MDS. Needle biopsy of the nodules histologically confirmed them to be moderately differentiated HCCs. The liver parenchyma was shown to be non-cirrhotic and a deposit of hemosiderin was also identified, consistent with a finding of haemochromatosis of the liver. Transarterial chemoembolization was performed to treat multiple HCCs. There are a number of reports describing HCC occurrence in non-cirrhotic patients with hereditary haemochromatosis. However, HCC in secondary haemochromatosis without cirrhosis is extremely rare.

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