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Related Experiment Videos

Vaccine efficacy in a measles immunisation programme.

V K Tohani1, F D Kennedy

  • 1Department of Public Health Medicine, Western Health and Social Services Board, Londonderry, Northern Ireland.

Communicable Disease Report. CDR Review
|April 24, 1992
PubMed
Summary
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A measles outbreak in Northern Ireland found that the measles vaccine was 94% effective. Even with high vaccination rates, some vaccinated children still contracted measles.

Area of Science:

  • Epidemiology
  • Immunology
  • Public Health

Background:

  • A measles outbreak occurred in Northern Ireland from October 1988 to March 1989.
  • A notable proportion of measles cases were observed in previously vaccinated children.

Purpose of the Study:

  • To rapidly estimate the efficacy of the measles vaccine during the outbreak.
  • To assess the impact of increasing vaccination coverage on measles case demographics.

Main Methods:

  • A study was initiated to provide a swift assessment of vaccine effectiveness.
  • Analysis of computerized records up to December 31, 1991, was conducted.

Main Results:

  • Measles vaccine efficacy was calculated at 94% (95% confidence limits: 91% to 96%).

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  • By December 1991, 94% of children in the study cohort had received the measles vaccine.

    • Conclusions:

    • The measles vaccine demonstrates high efficacy.
    • As measles vaccination coverage rises, an increasing proportion of measles cases will inevitably include vaccinated individuals.