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Replication of damaged DNA.

Alan R Lehmann1

  • 1Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK. a.r.lehmann@sussex.ac.uk

Cell Cycle (Georgetown, Tex.)
|July 10, 2003
PubMed
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Cells use specialized DNA polymerases for translesion synthesis to replicate past DNA damage. These polymerases have open structures and may switch via post-translational modifications.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • DNA damage is a continuous cellular event.
  • Cellular replication requires bypassing damaged DNA bases.

Purpose of the Study:

  • To explain the role of specialized DNA polymerases in bypassing DNA damage.
  • To explore the structural and functional characteristics of these polymerases.

Main Methods:

  • Analysis of DNA polymerase structures.
  • Investigation of polymerase localization within replication factories.
  • Review of emerging evidence on polymerase switching mechanisms.

Main Results:

  • Specialized DNA polymerases facilitate translesion synthesis.

Related Experiment Videos

  • These polymerases possess unique open structures for accommodating altered bases.
  • Some translesion polymerases localize to replication factories.

    • Conclusions:

    • Translesion synthesis polymerases are crucial for DNA replication fidelity.
    • Post-translational modifications may regulate the switch between replicative and translesion polymerases.