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Updated: Sep 23, 2026

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
10:09

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Published on: January 7, 2019

How cancers escape their oncogene habit

Sylvie Giuriato1, Dean W Felsher

  • 1Division of Oncology, Departments of Medicine and Pathology, Stanford University, Stanford, California 94305-5151, USA.

Cell Cycle (Georgetown, Tex.)
|July 10, 2003
PubMed

Insights

Targeting oncogenes can initially shrink cancers, but some tumors adapt and regrow. Understanding cancer

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Genetics

Background:

  • Oncogene inactivation can initially cause significant cancer regression.
  • Some cancers develop resistance to oncogene inactivation over time.
  • Tumor relapse indicates acquired oncogene independence.

Purpose of the Study:

  • To investigate the mechanisms of cancer relapse after oncogene inactivation.
  • To understand how cancers escape oncogene dependence.
  • To inform the development of more effective cancer therapies.

Main Methods:

  • Analysis of cancer cell lines and patient-derived xenografts.
  • Genetic and molecular profiling of relapsed tumors.
  • Functional assays to assess oncogene dependence and escape mechanisms.

Main Results:

  • Identified specific genetic alterations enabling cancer independence from oncogenes.
  • Demonstrated that acquired oncogene independence is a key mechanism of therapeutic relapse.
  • Characterized the molecular pathways involved in tumor escape.

Conclusions:

  • Understanding oncogene escape mechanisms is crucial for overcoming therapeutic resistance.
  • Targeting oncogenes requires strategies to prevent or overcome acquired independence.
  • This research provides insights for developing durable cancer treatments.

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