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Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate
Douglas H Deutschman1, Jeffrey S Carstens, Robert L Klepper
1SDSU Heart Institute and Department of Biology, San Diego State University, CA 92182-4614, USA.
American Heart Journal
|July 10, 2003
Summary
Serum sphingosine-1-phosphate (S1P) effectively predicts coronary artery disease (CAD) and its severity. A novel S1P-based composite score shows promise as a non-invasive indicator for obstructive CAD.
Area of Science:
- Cardiovascular Biology
- Biomarker Discovery
- Medical Diagnostics
Background:
- Sphingolipids are implicated as signaling molecules in cardiac stress and inflammation.
- Inflammation and myocardial ischemia are key factors in coronary artery disease (CAD).
Purpose of the Study:
- To investigate the predictive capability of serum sphingolipids for obstructive CAD.
- To evaluate serum sphingosine-1-phosphate (S1P) as a potential biomarker for CAD.
Main Methods:
- Coronary angiography performed on 308 patients.
- Serum sphingolipid levels, specifically S1P, were measured.
- Multivariate logistic regression analysis was employed.
Main Results:
- Serum S1P significantly predicted CAD (P <.001).
- S1P demonstrated higher predictive power for obstructive CAD than traditional risk factors (OR = 7.61).
- A composite score (S1PC) combining S1P, age, and sex predicted CAD occurrence and severity, with higher S1PC correlating to increased disease presence and severity.
Conclusions:
- Serum S1P is a strong predictor of both the presence and severity of coronary stenosis.
- An S1P-based composite score may serve as a novel, non-invasive marker for obstructive CAD.