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Related Experiment Videos

L-selectin: an emerging player in chemokine function.

Adil I Khan1, Paul Kubes

  • 1Immunology Research Group, Department of Physiology and Biophysics, University of Calgary Medical Center, Calgary, Alberta, Canada. pkubes@ucalgary.ca

Microcirculation (New York, N.Y. : 1994)
|July 10, 2003
PubMed
Summary

Leukocyte migration is crucial for immunity. This review highlights how selectin adhesion molecules enhance chemokine functions, impacting immune cell movement and inflammatory responses.

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Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Leukocyte emigration across the blood-endothelium barrier is vital for innate and adaptive immunity.
  • Chemokines are key chemoattractant cytokines regulating this process.
  • Emerging evidence implicates selectin adhesion molecules in modulating chemokine functions.

Purpose of the Study:

  • To review in vitro and in vivo studies on selectins enhancing chemokine functions.
  • To discuss the role of selectins in leukocyte chemotaxis.
  • To explore alterations in chemotaxis during inflammatory conditions.

Main Methods:

  • Review of in vitro and in vivo experimental studies.
  • Analysis of signaling pathways including phosphoinositide 3-kinase and p38 mitogen-activated protein kinase.
  • Examination of various chemoattractants and inflammatory settings.

Main Results:

  • Selectin adhesion molecules play a significant role in enhancing chemokine-mediated leukocyte migration.
  • Chemotaxis involves complex signaling pathways and interactions with specific chemoattractants.
  • Inflammatory conditions like endotoxemia and vasculitis can alter leukocyte chemotaxis.

Conclusions:

  • Selectins are important regulators of leukocyte trafficking by potentiating chemokine activity.
  • Understanding selectin-chemokine interactions provides insights into immune cell migration.
  • This knowledge is relevant for studying inflammatory diseases and developing therapeutic strategies.

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