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Tail-swing behavior: a novel animal model for anxiety.

M Ukai1, H Mitsunaga

  • 1Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan. ukai@ccmfs.meijo-u.ac.jp

Methods and Findings in Experimental and Clinical Pharmacology
|July 10, 2003
PubMed
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Diazepam and nitrazepam reduce tail-swing behavior in mice, a response linked to anxiety. This effect was reversed by flumazenil and bicuculline, suggesting a role for GABA(A) receptors.

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Tail-swing behavior in mice is a potential indicator of anxiety or fear.
  • Understanding the neurobiological underpinnings of such behaviors is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the effects of various drugs, including diazepam, nitrazepam, desipramine, and haloperidol, on mouse tail-swing behavior.
  • To characterize the specific mechanisms underlying diazepam's influence on this behavior.

Main Methods:

  • Mice were suspended by their upper bodies to elicit tail-swing behavior.
  • The duration of tail-swinging was measured after administration of different drug doses.
  • The effects of benzodiazepine receptor antagonists and GABA(A) receptor antagonists on diazepam-induced changes were assessed.

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Main Results:

  • Diazepam and nitrazepam significantly reduced tail-swing behavior without affecting ambulation or muscle tone.
  • Desipramine did not impact tail-swing behavior but reduced ambulation at higher doses.
  • Haloperidol decreased both tail-swing behavior and ambulation.
  • Flumazenil, beta-CCM, and bicuculline reversed diazepam's effect on tail-swing behavior.

Conclusions:

  • Tail-swing behavior in mice is likely associated with anxiety and/or fear.
  • The effects of diazepam on tail-swing behavior are mediated through benzodiazepine and GABA(A) receptors.