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[Therapy of mixed urinary incontinence]
1Klinik für Urologie und Kinderurologie, Klinikum Niederberg, Akad. Lehrkrankenhaus der Universität Duisburg-Essen, Velbert. goepel@klinikum-niederberg.de
Der Urologe. Ausg. A
|July 10, 2003
Summary
Tolterodine extended-release effectively treats mixed urinary incontinence in women. This study shows a nearly 60% symptom reduction after 8 weeks, establishing it as a successful therapy option.
Area of Science:
- Urology
- Pharmacology
- Clinical Trials
Background:
- Mixed urinary incontinence therapy remains controversial.
- Surgical interventions often fail to improve or may worsen urge symptoms.
Purpose of the Study:
- To evaluate the efficacy of Tolterodine extended-release in treating mixed urinary incontinence.
- To assess the impact of anticholinergic treatment on urge symptoms in these patients.
Main Methods:
- Prospective-randomized, double-blinded, multi-center trial.
- 410 female patients with mixed incontinence were treated with Tolterodine extended-release 4 mg once daily.
- Treatment duration was 8 weeks.
Main Results:
- A significant regression of mixed urinary incontinence symptoms was observed in nearly 60% of patients.
- Tolterodine extended-release demonstrated a positive therapeutic effect within 8 weeks.
Conclusions:
- Anticholinergic treatment with Tolterodine extended-release is a successful therapeutic option for women with mixed urinary incontinence.
- This medication offers a viable alternative for managing urge symptoms associated with mixed incontinence.
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