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Updated: Sep 23, 2026

Rapid Characterization of Genetic Parts with Cell-Free Systems
Published on: August 30, 2021
Chemical genetics: adding to the developmental biology toolbox
Jing-Ruey J Yeh1, Craig M Crews
1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.
Abstract:
Recent advances in cell and molecular biology have generated important tools to probe developmental questions. In addition, new genetic model systems such as Danio rerio now make large-scale vertebrate early developmental mutant screens feasible. Nonetheless, some developmental questions remain difficult to study because of the need for finer temporal, spatial, or tuneable control of gene function within a developmental system. New uses for old teratogens as well as novel chemical modulators of development have begun to fill this void.
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