Familial gestational trophoblastic disease

Familial molar pregnancies and gestational trophoblastic disease are exceedingly rare. In this case report, a family including four sisters and their cousin had molar pregnancies. Eldest sister had repeated molar pregnancies. Second sister had early abortion at her first pregnancy and partial molar pregnancy following blighted ovum by intrauterine insemination at her second pregnancy. Third sister had two molar pregnancies in a 2-year interval. Fourth and youngest sister has had gestational trophoblastic disease stage 1, following complete molar Pregnancy at her first pregnancy. A paternal-related cousin of this family has had gestational trophoblastic disease following complete molar pregnancy at her first pregnancy. No members of this family, except eldest sister, has given birth to a child.

complete and partial moles, repeated moles, gestational trophoblastic disease, early abortion, blighted ovum, and secondary infertility in this family demonstrate that a defective ovum with abnormal maternal genetic component is responsible.