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Effect of catechol derivatives on cell growth and lipoxygenase activity
Julie Simpson1, Rebecca Forrester, Michael J Tisdale
1School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK.
Abstract:
Derivatives of salicylic acid have been synthesized as potential lipoxygenase inhibitors. Agents containing a phenolic dihydroxy moiety showed potent (IC(50)10(-6)-10(-7) M) inhibition of the growth of murine colonic tumour cells in vitro, and were effective inhibitors of 5-, 12- and 15-lipoxygenase in intact cells. The catechols were also potent inhibitors of rabbit reticulocyte 15-lipoxygenase (IC(50) approximately 1 microM).
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