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DNA strand scission by a Cu(I).adenylated polymeric template: preliminary mechanistic and recycling studies
Sandeep Verma1, S G Srivatsan, Craig A Claussen
1Department of Chemistry, Indian Institute of Technology-Kanpur, Kanpur 208016 (UP), India. sverma@iitk.ac.in
Bioorganic & Medicinal Chemistry Letters
|July 11, 2003
Abstract:
Cleavage of a model phosphate ester and supercoiled plasmid DNA by a Cu(I).adenylated polymer template and preliminary mechanistic investigations are reported. A novel paradigm for the design of recyclable nucleolytic reagents allowing multiple use of this catalyst is also demonstrated