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Updated: Sep 23, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
[Chronobiological considerations for the management of human head and neck cancer]
C Focan1, D Focan-Henrard, F Kreutz
1Service d'oncologie médicale, clinique Saint-Joseph, rue de Hesbaye, 75, 4000, Liège, Belgique. christian.focan@lescliniquesstjoseph.be
Abstract:
The authors reviewed experimental and clinical data (ie, cell kinetics and its circadian control by cyclins, circadian expression of clock genes, chronotolerance to anticancer agents.) justifying to consider the temporal dimension in the medical treatment of human head and neck cancer. A complex infusional chronotherapyschedule (with 5-fluorouracil, folinic acid and carboplatin) was administered to 48 patients. Excellent tolerance and interesting tumour outcome allowed to conclude to an optimised therapeutic index.
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