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Related Experiment Videos

Toward surgical angiogenesis using slow-released basic fibroblast growth factor.

Yutaka Sakakibara1, Keiichi Tambara, Genichi Sakaguchi

  • 1Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|July 11, 2003
PubMed
Summary

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Biodegradable hydrogel microspheres delivering basic fibroblast growth factor (bFGF) improved heart function in pigs with myocardial infarction. This slow-release bFGF therapy promotes angiogenesis and may enhance coronary bypass surgery outcomes.

Area of Science:

  • Cardiovascular Research
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Therapeutic angiogenesis for coronary artery disease using basic fibroblast growth factor (bFGF) shows variable effectiveness.
  • Investigating novel delivery methods for bFGF is crucial for improving treatment outcomes.

Purpose of the Study:

  • To evaluate the distribution of bFGF in rat hearts using different administration methods.
  • To assess the efficacy of slow-released bFGF via biodegradable hydrogel microspheres in a pig myocardial infarction model.
  • To explore potential benefits for enhanced coronary bypass surgery.

Main Methods:

  • Rats and pigs with induced myocardial infarction were used.
  • Different bFGF administration methods (free form vs. microspheres) were tested in rats for distribution analysis.

Related Experiment Videos

  • Pigs received either bFGF microspheres or control microspheres in the left ventricular wall post-infarction.

    • Main Results:

    • Intramyocardial administration of bFGF microspheres resulted in higher bFGF retention in rat hearts.
    • In pigs, bFGF microspheres significantly reduced left ventricular (LV) diastolic diameter and improved LV end-systolic elastance.
    • Microscopic analysis revealed increased neovascularization and vascular density in the bFGF-treated pig hearts, with reduced LV wall expansion.

    Conclusions:

    • Biodegradable hydrogel microspheres effectively deliver bFGF, improving LV function and inhibiting adverse remodeling via angiogenesis in pigs with chronic myocardial infarction.
    • This bFGF microsphere approach shows promise for revascularizing small, ungraftable vessels and potentially improving outcomes in coronary bypass surgery.