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Pegylated interferon and ribavirin-induced interstitial pneumonitis with ARDS
Sandra Abi-Nassif1, Eugene J Mark, Robert B Fogel
1Department of Pharmacy, Division of Pulmonary and Critical Care, and Massachusetts General Hospital, Boston, MA 02114, USA. sabinassif@partners.org
Chest
|July 11, 2003
Abstract:
A 49-year-old man with cirrhosis due to hepatitis C virus developed interstitial pneumonitis documented by surgical lung biopsy specimen evaluation after two weekly doses of pegylated interferon-alpha(2)b in combination with ribavirin. He developed ARDS and died after 26 days of hospitalization from multisystem organ failure. This case suggests that interstitial pulmonary disease can occur with pegylated interferon-alpha(2)b therapy.