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Multiple sclerosis-like disease secondary to alpha interferon.

Toshihiko Matsuo1, Ryu Takabatake

  • 1Department of Ophthalmology, Okayama University Medical School, Okayama City, Japan. matsuot@cc.okayama-u.ac.jp

Ocular Immunology and Inflammation
|July 11, 2003
PubMed
Summary

Bilateral optic neuritis and other neurological symptoms, mimicking multiple sclerosis, can be adverse effects of interferon alpha treatments. Prompt corticosteroid therapy may lead to partial visual recovery.

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Area of Science:

  • Neuro-immunology
  • Hepatology
  • Oncology

Background:

  • Interferon alpha is used to treat chronic active hepatitis C and chronic myelogenous leukemia.
  • Adverse effects of interferon therapy can include neurological complications.

Observation:

  • Two women developed bilateral optic neuritis after prolonged interferon alpha administration.
  • Neurological symptoms included sensory and motor deficits, and bowel/bladder dysfunction, mimicking multiple sclerosis.

Findings:

  • Magnetic resonance imaging revealed white matter lesions in the brain and spinal cord.
  • Cerebrospinal fluid analysis showed increased mononuclear cells and protein, including myelin basic protein.
  • Pulse corticosteroid therapy resulted in partial visual recovery in both patients.

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Implications:

  • Optic neuritis and related neurological signs should be recognized as potential adverse effects of interferon alpha.
  • This finding is crucial for clinicians managing patients on interferon therapy.
  • Early recognition and management may improve patient outcomes.