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Updated: Jul 28, 2026

Fabrication of Compressed Hosiery and Measurement of its Pressure Characteristic Exerted on the Lower Limbs
Published on: May 27, 2020
Randomized clinical trial and economic analysis of four-layer compression bandaging for venous ulcers
J F O'Brien1, P A Grace, I J Perry
1Department of Vascular Surgery, Mid-Western Regional Hospital, Limerick, Ireland.
Background:
The aim of this study was to compare the cost-effectiveness of four-layer compression bandaging for venous leg ulcers with that of other available treatments.
Methods:
In this pragmatic trial, 200 patients with a venous leg ulcer were randomized either to four-layer bandaging (intervention group; n = 100) or to continue their usual system of care (control group; n = 100). The follow-up for each patient was 12 weeks. Analysis was by intention to treat; the main outcome measures were time to healing and cost to the health board per leg healed.
Results:
Baseline characteristics were well matched in the two groups. The Kaplan-Meier estimate of the healing rate at 3 months was 54 per cent with four-layer bandaging and 34 per cent in the control group. Throughout the 3 months, four-layer bandaging healed leg ulcers significantly earlier (P = 0.006). There was a significant reduction in the median cost per leg healed with four-layer bandaging (euro 210 versus euro 234; P = 0.040).
Conclusion:
Four-layer bandaging is currently the most effective method of treating venous leg ulcers in a community setting.
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