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Related Experiment Videos

[Experimental and clinical islets transplantation. Current status].

K F Federlin1, R G Bretzel, B J Hering

  • 1III. Medizinische Klinik und Poliklinik, Justus-Liebig-Universität Giessen.

Zentralblatt Fur Chirurgie
|January 1, 1992
PubMed
Summary

Islet transplantation shows promise for treating diabetes, offering long-term normoglycemia in animal models. While challenges remain in human applications, its advantages over organ transplants suggest future therapeutic potential.

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The prognostic significance of glutamic acid decarboxylase antibodies in patients with chronic pancreatitis undergoing total pancreatectomy with islet autotransplantation.

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Islet product characteristics and factors related to successful human islet transplantation from the Collaborative Islet Transplant Registry (CITR) 1999-2010.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014

Area of Science:

  • Endocrinology and Metabolism
  • Transplantation Immunology
  • Regenerative Medicine

Context:

  • Enzymatic isolation of islets of Langerhans has advanced over 25 years.
  • Islet transplantation has shown success in syngeneic and allogeneic models in rodents and larger animals.
  • Significant challenges hinder human islet transplantation success rates.

Purpose:

  • To review the progress and challenges in islet transplantation for diabetes treatment.
  • To highlight the potential of islet transplantation as a therapeutic strategy.
  • To discuss future directions including xenotransplantation.

Summary:

  • Syngeneic islet transplantation effectively manages diabetes and prevents late complications in animal models.
  • Allogeneic islet transplantation requires immunomodulation to overcome rejection.

Related Experiment Videos

  • Human islet transplantation faces hurdles like islet damage, low yield, and immune rejection, though some patients achieve insulin independence.

    • Impact:

    • Successful islet transplantation offers a less invasive alternative to whole pancreas transplantation.
    • Potential for repeated transplantation and future xenotransplantation expands therapeutic options.
    • Advances in islet isolation and transplantation could significantly improve diabetes management.