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[Heart transplantation--indications and results]
Zentralblatt Fur Chirurgie
|January 1, 1992
Summary
Heart transplantation is a standard treatment for heart failure, with 81% one-year survival. Post-transplant risks include infection, cardiac disease, and medication side effects, but mechanical assist devices can treat acute failure.
Area of Science:
- Cardiology
- Transplantation Medicine
- Immunology
Context:
- Heart transplantation is a well-established treatment for end-stage heart failure.
- Recipient and donor selection criteria have broadened, improving accessibility.
- One-year survival rates have significantly improved, reaching 81%.
Purpose:
- To review the current landscape of heart transplantation, including indications, outcomes, and challenges.
- To highlight the evolving nature of donor and recipient criteria.
- To discuss immediate and long-term complications and management strategies.
Summary:
- Heart transplantation is a standard therapy for irreversible heart failure, with extended criteria and an 81% one-year survival rate.
- Postoperative risks include infection, while long-term concerns involve cardiac allograft vasculopathy, organ dysfunction from immunosuppression, hypertension, and malignancies.
- Retransplantation is an option for chronic failure, and mechanical circulatory support devices manage acute pre-transplant failure.
Impact:
- Improved understanding of heart transplant outcomes and long-term management.
- Highlights the critical role of managing post-transplant complications for patient longevity.
- Informs clinical practice regarding recipient selection, risk assessment, and follow-up care.