Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evidence that neurofibrillary tangles undergo glial modification.

K Ikeda1, H Akiyama, C Haga

  • 1Department of Neuropathology, Tokyo Institute of Psychiatry, Japan.

Acta Neuropathologica
|January 1, 1992
PubMed
Summary

Extracellular neurofibrillary tangles (NFTs) interact with microglia and astrocytes. These ghost tangles undergo structural changes and may be discharged into vessels or formed within astrocytic end-feet.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Japanese encephalitis - serial CT findings and neuropathology in an autopsy case.

Clinical neuropathology·2009
Same author

Distribution of basal ganglia lesions in diffuse neurofibrillary tangles with calcification: a clinicopathological study of five autopsy cases.

Acta neuropathologica·2002
Same author

Neuronal degeneration and glial cell-responses following trimethyltin intoxication in the rat.

Acta neuropathologica·2002
Same author

Distribution of cerebral cortical lesions in Pick's disease with Pick bodies: a clinicopathological study of six autopsy cases showing unusual clinical presentations.

Acta neuropathologica·2002
Same author

Distribution of basal ganglia lesions in generalized variant of Pick's disease: a clinicopathological study of four autopsy cases.

Acta neuropathologica·2001
Same author

Argyrophilic grain disease mimicking temporal Pick's disease: a clinical, radiological, and pathological study of an autopsy case with a clinical course of 15 years.

Acta neuropathologica·2001

Area of Science:

  • Neuroscience
  • Cell Biology
  • Pathology

Background:

  • Neurofibrillary tangles (NFTs) are key pathological hallmarks of Alzheimer's disease.
  • The extracellular presence and cellular interactions of NFTs are not fully understood.

Purpose of the Study:

  • To investigate the cellular interactions and extracellular fate of neurofibrillary tangles.
  • To explore potential structural and immunocytochemical modifications of extracellular NFTs.

Main Methods:

  • Electron microscopy was utilized to observe NFTs in the vascular region.
  • Immunocytochemical analysis was performed to assess modifications.

Main Results:

  • Extracellular NFTs were observed to be associated with microglia.

Related Experiment Videos

  • Astrocytic processes were seen invading the extracellular NFTs.
  • Electron microscopy revealed NFTs potentially being discharged into blood vessels or formed within astrocytic end-feet.

    • Conclusions:

    • Extracellular NFTs undergo significant cellular interactions and modifications.
    • The vascular system may play a role in the clearance or formation of NFTs.