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Related Experiment Videos

Cerebral morbidity in preterm twins.

W Rettwitz-Volk1, T M Tran, A Veldman

  • 1Department of Pediatrics, Division of Neonatology, University Hospital Frankfurt am Main, Germany.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|July 12, 2003
PubMed
Summary

Preterm twins face higher risks of severe brain bleeds and respiratory issues compared to singletons. However, mortality rates and other morbidities were similar, with no birth order differences observed.

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Area of Science:

  • Neonatal Medicine
  • Perinatology
  • Pediatric Neurology

Background:

  • The neonatal morbidity risks for twins compared to singletons are debated.
  • Preterm twins may face unique cerebral and other morbidities.

Purpose of the Study:

  • To investigate the specific risks of preterm twins, focusing on cerebral morbidity.
  • To compare neonatal morbidity between twins and singletons born between 24 and 37 weeks' gestation.

Main Methods:

  • Retrospective chart review of 230 twin pairs and matched singletons.
  • Inclusion criteria: gestational age 24–37 weeks, born between 1990–1998.
  • Data collected from a single level-III neonatal intensive care unit.

Main Results:

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  • Twin pregnancies had higher rates of preterm contractions (OR 4.03) but lower rates of gestosis (OR 0.14).
  • Twins had significantly higher rates of high-grade intracranial hemorrhage (Grades III-IV) (OR 3.75), particularly those <32 weeks' gestation (OR 3.31).
  • Respiratory distress syndrome was more common in twins <32 weeks' gestation (OR 1.93); no differences were found between first- and second-born twins.

Conclusions:

  • Preterm twins (<37 weeks) showed increased incidence of high-grade intraventricular hemorrhage, irrespective of birth order.
  • Periventricular leukomalacia was twice as common in twins compared to singletons.
  • Mortality and most morbidities were similar, except for respiratory distress syndrome in twins <32 weeks' gestation.