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[Serum troponin T in patients with chronic Chagas disease]

Ana L Basquiera1, Ricardo Capra, Mirtha Omelianiuk

  • 1Hospital Privado Centro Médico de Córdoba. Córdoba. Argentina. anabasquiera@arnet.com.ar

Revista Espanola De Cardiologia
|July 12, 2003
PubMed

Insights

High-sensitivity troponin T assays did not detect early myocardial damage in chronic Chagas disease patients. Troponin T levels were not associated with cardiac lesions in this early-stage cohort.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Biomarkers

Context:

  • High serum troponin T (TnT) levels are established markers of myocardial damage in nonischemic cardiomyopathies.
  • Chagas disease can lead to chronic cardiomyopathy, but early detection of myocardial damage remains challenging.

Purpose:

  • To evaluate if a highly sensitive troponin T assay can identify early-stage myocardial damage in patients with chronic Chagas disease.

Summary:

  • Thirty-nine outpatients with serologic diagnosis of Chagas disease were assessed. Patients were categorized based on cardiac involvement: no lesions (15), electrocardiographic changes only (15), and echocardiographic alterations (9).
  • Highly sensitive troponin T (hs-TnT) levels were measured. Only one patient (11.11%) in the echocardiographic alteration group had a positive TnT result, coinciding with the lowest ejection fraction (29%) and largest left ventricular diastolic diameter (77 mm).

Impact:

  • The study suggests that highly sensitive troponin T assays are not associated with early myocardial damage in chronic Chagas disease.
  • Further research may be needed to identify reliable biomarkers for early detection of Chagas cardiomyopathy.

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