Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetics of exceptional longevity.

Thomas Perls1, Dellara Terry

  • 1Geriatrics Section, Boston University Medical Center, 88 East Newton Street, F4, Boston, MA 02118, USA. thperls@bu.edu

Experimental Gerontology
|July 12, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Utility of Polygenic Risk Scores in Families with Exceptional Longevity.

medRxiv : the preprint server for health sciences·2025
Same author

Tailored Approach to Designing a Digital Research Platform for Adults Aged 95 and Older: SuperAgers Family Study.

The journals of gerontology. Series A, Biological sciences and medical sciences·2025
Same author

Race and ethnicity dynamics in survival to 100 years in the United States.

Journal of internal medicine·2024
Same author

The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank.

GeroScience·2024
Same author

Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.

Frontiers in genetics·2023
Same author

SuperAger Initiative: unlocking the genetic potential of exceptional longevity.

Nature aging·2023
Same journal

Astragalus membranaceus and Salvia miltiorrhiza injections confer cardioprotection via SERCA/SIRT1-mediated Ca<sup>2+</sup> regulation.

Experimental gerontology·2026
Same journal

Ayurvedic nutraceutical, Chyawanprash, enhances longevity and stress resilience via mitochondrial and muscular health in C. elegans model of ageing.

Experimental gerontology·2026
Same journal

Activation of Sirt3 reprograms mitochondrial function to regenerate intervertebral disc degeneration.

Experimental gerontology·2026
Same journal

Sit-to-stand power shows greater magnitude associations with radial bone strength compared to handgrip strength in adults aged 60-95 years: A cross-sectional study.

Experimental gerontology·2026
Same journal

Impact of simultaneous motor-cognitive training on motor capacities in older adults: A quasi-randomized parallel controlled trial.

Experimental gerontology·2026
Same journal

Triglyceride-glucose-related metabolic indices, phenotypic aging, and incident pulmonary embolism.

Experimental gerontology·2026
See all related articles

Exceptional longevity in centenarians has a strong genetic component. Studying families of centenarians reveals genetic factors influencing slow aging and reduced disease risk.

Area of Science:

  • Gerontology and Genetics
  • Human Longevity Research

Background:

  • Centenarians represent the extreme of human life expectancy.
  • Exceptional longevity is known to have a significant genetic influence.
  • Genetic studies, including pedigree and molecular analyses, support this link.

Purpose of the Study:

  • To explore the genetic factors contributing to exceptional longevity.
  • To investigate the role of familial studies in understanding aging.
  • To identify genetic determinants of delayed age-related diseases.

Main Methods:

  • Analysis of pedigree data from centenarian families.
  • Molecular genetic studies focusing on centenarians and their relatives.
  • Comparative mortality risk assessment of siblings of centenarians.

Related Experiment Videos

Main Results:

  • A genetic locus on chromosome 4 has been identified, influencing aging and disease susceptibility.
  • Siblings of centenarians show a significantly higher likelihood of reaching extreme old age.
  • Siblings of centenarians exhibit half the mortality risk compared to their birth cohort.

Conclusions:

  • Centenarian studies offer powerful insights into genetic modulation of aging.
  • Familial studies, particularly of centenarians' siblings and children, are crucial for understanding longevity.
  • Children of centenarians serve as a valuable model for studying slow aging and disease escape.