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Related Experiment Videos

Nuclear receptor coactivator function in reproductive physiology and behavior.

Heather A Molenda1, Caitlin P Kilts, Rachel L Allen

  • 1Center for Neuroendocrine Studies, Neuroscience and Behavior Program, University of Massachusetts, Amherst, Massachusetts 01003, USA.

Biology of Reproduction
|July 12, 2003
PubMed
Summary

Nuclear receptor coactivators are essential for steroid hormone action. This review explores their mechanisms and crucial roles in reproductive physiology and brain development.

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Area of Science:

  • Molecular Endocrinology
  • Neuroendocrinology
  • Reproductive Biology

Background:

  • Gonadal steroid hormones regulate gene expression impacting reproductive physiology and behavior.
  • Steroid hormone effects are mediated by intracellular receptors, part of the nuclear receptor superfamily.
  • Nuclear receptor coactivators are known to be crucial for efficient steroid receptor transcriptional activity in vitro.

Purpose of the Study:

  • To review the general mechanisms of nuclear receptor coactivators in steroid-dependent gene transcription.
  • To discuss recent findings on the function of these coactivators in reproductive physiology and behavior.
  • To highlight their roles in steroid-dependent brain development.

Main Methods:

  • Literature review of in vitro and in vivo studies.

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  • Analysis of coactivator involvement in gene transcription.
  • Synthesis of current research on coactivator functions in reproductive tissues and the brain.

    • Main Results:

    • Nuclear receptor coactivators are widely distributed in steroid hormone-responsive tissues.
    • Emerging evidence demonstrates their critical roles in vivo, beyond in vitro observations.
    • Coactivators are integral to steroid-dependent processes in the brain, reproductive tract, and mammary gland.

    Conclusions:

    • Nuclear receptor coactivators are vital for mediating steroid hormone actions.
    • Understanding coactivator function is key to comprehending reproductive physiology, behavior, and brain development.
    • Further research is needed to fully elucidate their in vivo roles and therapeutic potential.