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Diurnal variation of urinary histamine and 1-methylhistamine excretion in healthy children

S Schulze1, B Niggemann, A N Savaser

  • 1University Children's Hospital (KAVH), Berlin, Germany.

Allergy
|December 1, 1992
PubMed

Insights

Urinary 1-methylhistamine is a better marker for monitoring immediate hypersensitivity reactions in children. It shows less diurnal variation compared to urinary histamine, making it more reliable for clinical use.

Area of Science:

  • Pediatric Allergy and Immunology
  • Biochemical Monitoring

Background:

  • Immediate hypersensitivity reactions require reliable noninvasive monitoring methods in children.
  • Urinary histamine and its metabolite, 1-methylhistamine, are potential biomarkers.

Purpose of the Study:

  • To evaluate the diurnal variation and food intake influence on urinary histamine and 1-methylhistamine excretion in children.
  • To determine the suitability of these markers for monitoring hypersensitivity reactions.

Main Methods:

  • Radioimmunoassay determination of histamine and 1-methylhistamine in spontaneous urine samples.
  • Study conducted on 14 healthy nonatopic children aged 2-16 years.

Main Results:

  • Urinary histamine excretion showed significantly higher diurnal variation (45%) than 1-methylhistamine (24%).
  • Neither marker exhibited a clear circadian rhythm or significant influence from food intake.
  • The rapid blood circulation half-life of histamine likely contributes to its excretion variability.

Conclusions:

  • Urinary 1-methylhistamine is less affected by diurnal fluctuations than histamine.
  • 1-methylhistamine is a more suitable biomarker than histamine for noninvasive monitoring of immediate hypersensitivity in pediatric populations.

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