Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Matching accessories.

Steven M Foord1

  • 1Target Bioinformatics, GlaxoSmithKline Medicine Research Centre, Stevenage, Hertfordshire SG1 2NY, UK. steven.m.foord@gsk.com

Science'S STKE : Signal Transduction Knowledge Environment
|July 12, 2003
PubMed
Summary

Accessory proteins like Receptor Activity-Modifying Proteins (RAMPs) and M10 proteins modulate G protein-coupled receptor (GPCR) function. These proteins heterodimerize with GPCRs, influencing ligand recognition and signaling pathways.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Heterodimerization of the GABAB receptor-implications for GPCR signaling and drug discovery.

Advances in pharmacology (San Diego, Calif.)·2010
Same author

Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery.

Nature reviews. Drug discovery·2009
Same author

Definition of the G protein-coupled receptor transmembrane bundle binding pocket and calculation of receptor similarities for drug design.

Journal of medicinal chemistry·2009
Same author

International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature.

Pharmacological reviews·2009
Same author

The G protein-coupled receptor subset of the dog genome is more similar to that in humans than rodents.

BMC genomics·2009
Same author

IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels.

Nucleic acids research·2008

Area of Science:

  • Molecular and Cellular Biology
  • Neuroscience
  • Immunology

Background:

  • Heterodimerization of G protein-coupled receptors (GPCRs) increases ligand recognition complexity and signaling diversity.
  • Accessory proteins often associate with receptors early in cell surface transport, potentially influencing their function.
  • Receptor Activity-Modifying Proteins (RAMPs) are known to heterodimerize with GPCRs, enabling multiple ligand recognition and varied signaling responses.

Purpose of the Study:

  • To investigate the association between M10 family major histocompatibility complex (MHC) class 1b proteins and murine vomeronasal V2R receptors.
  • To explore the role of M10 proteins in the cell surface transport and functional modulation of V2R receptors.

Main Methods:

  • Investigated protein-protein interactions between M10 proteins and V2R receptors.
  • Utilized cell surface transport assays to determine the role of M10 in V2R trafficking.

Main Results:

  • M10 family proteins were found to associate with murine V2R receptors.
  • M10 proteins facilitate the escort of V2R receptors to the cell surface.

Conclusions:

  • M10 proteins function as accessory proteins for V2R receptors, similar to RAMPs for other GPCRs.
  • The precise functional impact of M10 on V2R activity requires further investigation.

Related Experiment Videos