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Related Experiment Videos

[Erythroderma induced by teicoplanin].

C Paul1, M Janier, J Carlet

  • 1Service de Dermatologie, Hôpital Saint-Joseph, Paris.

Annales De Dermatologie Et De Venereologie
|January 1, 1992
PubMed
Summary

A patient developed erythroderma during teicoplanin treatment for staphylococcal septicaemia. Switching to vancomycin resolved the condition, indicating a teicoplanin allergy and safe vancomycin use in such cases.

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Area of Science:

  • Clinical Medicine
  • Pharmacology
  • Infectious Diseases

Background:

  • Staphylococcal septicaemia is a serious bloodstream infection.
  • Erythroderma is a widespread skin inflammation.
  • Teicoplanin is an antibiotic used for Gram-positive bacterial infections.

Observation:

  • A 38-year-old man presented with erythroderma during teicoplanin therapy for staphylococcal septicaemia.
  • Clinical signs suggested staphylococcal toxic shock syndrome.
  • The patient experienced high fever, shock, and erythroderma.

Findings:

  • Discontinuation of teicoplanin and initiation of vancomycin led to a favorable clinical outcome.
  • A positive reintroduction test confirmed teicoplanin as the causative agent.

Related Experiment Videos

  • This case highlights diagnostic challenges of erythroderma in intensive care settings.

    • Implications:

    • Vancomycin can be a safe alternative for patients with teicoplanin hypersensitivity.
    • Careful diagnosis is crucial for managing severe skin reactions in critically ill patients.
    • Understanding drug-induced erythroderma aids in optimizing antibiotic therapy.