Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Pathophysiology of cutaneous inflammation.

B J Nickoloff¹

¹Department of Pathology, University of Michigan Medical School, Ann Arbor.

Archives of Dermatological Research

|January 1, 1992

Summary

Epidermal keratinocytes, once viewed as passive skin cells, are now recognized as active participants in initiating and perpetuating inflammatory skin conditions. This research highlights their dynamic immunomodulatory capacity in various cutaneous reactions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The many molecular mysteries of melanoma.

Methods in molecular medicine·2012

Same author

2-deoxyglucose sensitizes melanoma cells to TRAIL-induced apoptosis which is reduced by mannose.

Biochemical and biophysical research communications·2010

Same author

Targeting glutamine metabolism sensitizes melanoma cells to TRAIL-induced death.

Biochemical and biophysical research communications·2010

Same author

3-Bromopyruvate induces necrotic cell death in sensitive melanoma cell lines.

Biochemical and biophysical research communications·2010

Same author

Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells.

Oncogene·2008

Same author

Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility.

Oncogene·2006

Area of Science:

Dermatology
Immunology
Cell Biology

Background:

Historically, skin has been viewed as a protective barrier, with epidermal keratinocytes primarily recognized for structural roles.
Keratinocytes were considered passive targets in inflammatory skin conditions, affected by infiltrating leukocytes.

Purpose of the Study:

To challenge the traditional view of keratinocytes as passive cells in skin inflammation.
To highlight the active role and immunomodulatory capacity of epidermal keratinocytes in cutaneous inflammatory reactions.

Main Methods:

Review of in vitro and in vivo evidence.
Emphasis on the immunomodulatory functions of epidermal keratinocytes.

Main Results:

Accumulating evidence supports keratinocytes actively initiating and perpetuating numerous cutaneous inflammatory reactions.
Keratinocytes are involved with a diverse array of inciting agents in skin inflammation.

Conclusions:

Epidermal keratinocytes possess significant dynamic immunomodulatory capabilities.
A novel perspective positions keratinocytes as key active players in skin immunity and inflammation, not just passive targets.

Related Experiment Videos