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Related Experiment Videos

Submural histopathologic changes attributable to peracute laminitis in horses.

Sherry J Morgan1, David M Hood, Ilka P Wagner

  • 1Department of Pathology, Abbott Laboratories, Abbott Park, IL 60064, USA.

American Journal of Veterinary Research
|July 15, 2003
PubMed
Summary

Subtle histopathologic changes in horse hooves occur early in peracute laminitis, even before clinical signs. These dermal and epidermal lesions progress with lameness severity and duration.

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Area of Science:

  • Equine pathology
  • Veterinary dermatology
  • Laminitis research

Background:

  • Laminitis is a common equine disease affecting the hoof lamellae.
  • Early histopathologic changes are crucial for understanding laminitis progression.
  • Subclinical laminitis may contribute to chronic hoof issues.

Purpose of the Study:

  • To detail submural histopathologic alterations in horses experiencing peracute laminitis.
  • To correlate these changes with clinical signs and lameness duration.

Main Methods:

  • A concurrent-control study involving 20 adult horses (10 with carbohydrate-induced laminitis, 10 controls).
  • Tissue biopsies were collected 4-8 hours after lameness onset or 72 hours post-carbohydrate administration.
  • Histopathologic analysis using H&E, Masson's trichrome, and PAS stains.

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Main Results:

  • Dermal and epidermal lesions were present before visible basement membrane separation.
  • Lesions were observed in horses without detectable lameness.
  • Changes were nonspecific, progressive with lameness, and correlated with severity and duration.

Conclusions:

  • Basement membrane separation is a delayed event in acute laminitis pathogenesis.
  • Digital vascular hypoperfusion is a likely underlying cause.
  • Repeated subclinical laminitis episodes may lead to chronic changes without acute clinical signs.