Related Experiment Videos
Idiopathic myelofibrosis with refractory massive ascites
Mihoko Yotsumoto1, Fumihiro Ishida, Toshiro Ito
1Second Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621.
Internal Medicine (Tokyo, Japan)
|July 15, 2003
Summary
Idiopathic myelofibrosis can cause refractory ascites due to extramedullary hematopoiesis. Cytological analysis of ascitic fluid confirmed this condition, aiding diagnosis.
Area of Science:
- Hematology
- Oncology
Background:
- Idiopathic myelofibrosis is a chronic bone marrow disorder.
- Refractory ascites is a challenging clinical complication.
Observation:
- A 55-year-old woman with idiopathic myelofibrosis developed massive, refractory ascites.
- Ascitic fluid analysis revealed granulocytes, erythroblasts, and megakaryocytes with trisomy 8.
Findings:
- The ascites was exudative and presumed to be from peritoneal extramedullary hematopoiesis.
- Abnormal karyotype in ascitic fluid cells matched peripheral blood, confirming extramedullary hematopoiesis.
Implications:
- This case highlights extramedullary hematopoiesis as a cause of ascites in myelofibrosis.
- Cytological and karyotypic analysis of ascitic fluid aids in differential diagnosis.