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Thrombophilic mutations are a main risk factor for placental abruption
Fabio Facchinetti1, Luca Marozio, Elvira Grandone
1Mother-Infant Dept, Univ. of Modena & Reggio Emilia, Italy. Facchi@unimore.it
Haematologica
|July 15, 2003
Summary
Inherited thrombophilic mutations, specifically factor V Leiden and factor II A20210, significantly increase the risk of placental abruption in Caucasian women. Genetic testing is recommended for those experiencing severe placental abruption.
Area of Science:
- Genetics
- Obstetrics
- Hematology
Background:
- Placental abruption is a serious obstetric complication.
- Inherited thrombophilias are associated with adverse pregnancy outcomes.
Purpose of the Study:
- To investigate the association between factor V Leiden and factor II A20210 mutations and placental abruption in Caucasian women.
Main Methods:
- A multi-center, case-control study involving 50 women with placental abruption and 100 controls.
- Inclusion criteria focused on women with abruptio placentae requiring immediate delivery and specific demographic/parity matching.
Main Results:
- Carriership of factor V Leiden mutation showed an odds ratio (OR) of 9.12.
- Carriership of factor II A20210 mutation showed an OR of 12.25.
- The prevalence of these mutations was similar in patients with and without pre-eclampsia.
Conclusions:
- Factor V Leiden and factor II A20210 mutations are significant risk factors for placental abruption in Caucasians.
- This risk is independent of pre-eclampsia development.
- Evaluation for these genetic mutations is advised for women with severe placental abruption.