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E4orf3 is necessary for enhanced S-phase replication of cell cycle-restricted subgroup C adenoviruses
Robin N Shepard1, David A Ornelles
1Department of Microbiology and Immunology, Wake Forest University School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157-1064, USA.
Journal of Virology
|July 15, 2003
Abstract:
E1B-55K-mutant or E4orf6-mutant adenoviruses replicate more effectively after infecting cells in S phase than after infecting cells in G(1). Enhanced S-phase replication of the E4orf6-mutant viruses requires the E4orf3 gene. This report demonstrates that the E4orf3 gene is also required for enhanced S-phase replication of the E1B-55K-mutant virus.