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Evolution of complement as an effector system in innate and adaptive immunity.

J Oriol Sunyer1, Hani Boshra, Gema Lorenzo

  • 1Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. sunyer@vet.upenn.edu

Immunologic Research
|July 15, 2003
PubMed
Summary

The complement system bridges innate and adaptive immunity. Researchers are studying teleost fish, with their diverse C3 protein, to understand complement

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Area of Science:

  • Evolutionary immunology
  • Comparative immunology
  • Innate and adaptive immunity

Background:

  • The complement system is crucial for innate immunity and also contributes to acquired immune responses.
  • This defense mechanism evolved from innate recognition in invertebrates to bridging innate and adaptive immunity in vertebrates.
  • Understanding complement's evolutionary role requires studying species with early adaptive immune systems.

Purpose of the Study:

  • To investigate the evolutionary role of the complement system in bridging innate and adaptive immunity.
  • To explore the function of complement in both innate and adaptive immune responses within teleost fish.

Main Methods:

  • Utilizing teleost fish as an animal model due to their ancient adaptive immune system.
  • Focusing on the structural and functional diversity of the complement component C3 in teleost fish.

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Main Results:

  • Teleost fish possess an ancient adaptive immune response.
  • The complement system in teleost fish exhibits unique diversity in its C3 protein.

Conclusions:

  • Teleost fish provide a valuable model for studying the evolution of the complement system.
  • The diverse C3 protein in teleost fish offers insights into the complement system's role as a bridge between innate and adaptive immunity.