Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recent developments in the HIV neuropathies.

Carlos A Luciano1, Carlos A Pardo, Justin C McArthur

  • 1Specialized Neuroscience Research Program in NeuroAIDS, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico 00936, USA.

Current Opinion in Neurology
|July 15, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Autoimmune neuroinflammation leads to neuronal death via MIF nuclease-mediated parthanatos.

Nature neuroscience·2026
Same author

Autoimmune neuroinflammation leads to neuronal death via MIF nuclease-mediated parthanatos.

Nature neuroscience·2026
Same author

Anti-CD320 Autoantibodies and Central Nervous System Vitamin B12 Deficiency in Idiopathic Myelopathy.

medRxiv : the preprint server for health sciences·2026
Same author

Defining Relapse and Disease Activity in Neurosarcoidosis: A Systematic Review and Proposed Framework.

Neurology. Clinical practice·2026
Same author

TEAM Sarcoidosis: Creating a Multidisciplinary Care Team for Complex Clinical Management.

Chest·2025
Same author

Neurosarcoidosis in Critical Care, Internal, and Pulmonary Medicine: A Practical Approach.

Seminars in respiratory and critical care medicine·2025
Same journal

Movement disorders and Parkinson's disease: collaborative and interdisciplinary research to advance understanding of neural circuit dysfunction, pathophysiology, and care: new horizons in technology, neuroimaging, neurophysiology, and genetics toward personalized medicine.

Current opinion in neurology·2026
Same journal

Editorial introduction.

Current opinion in neurology·2026
Same journal

Multimodal mapping of balance dysfunction in Parkinson's disease: a consensus roadmap for research and intervention.

Current opinion in neurology·2026
Same journal

Tourette syndrome: brain neurophysiology, circuit dysfunction, and neuromodulation across invasive and noninvasive approaches.

Current opinion in neurology·2026
Same journal

Dystonia: from phenotypes to genetics and therapeutic advances.

Current opinion in neurology·2026
Same journal

What can we learn from eye movements in movement disorders and Parkinson's disease?

Current opinion in neurology·2026
See all related articles

Peripheral neuropathies are common in HIV infection, influenced by antiretroviral therapy. Understanding risk factors and mechanisms is key for better management and improved quality of life for patients.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Pharmacology

Background:

  • Peripheral neuropathies are a significant neurological complication in HIV infection.
  • Highly active antiretroviral therapy (HAART) has altered the landscape of these neuropathies.
  • Understanding evolving risk factors, markers, and pathogenic mechanisms is crucial.

Purpose of the Study:

  • To review current understanding of HIV-associated peripheral neuropathies.
  • To explore changing frequencies and spectra of neuropathies with new treatments.
  • To highlight critical factors for improved management.

Main Methods:

  • Review of recent studies on risk factors, markers, and pathogenesis.
  • Analysis of immune-mediated and toxic factors in neuropathy development.

Related Experiment Videos

  • Evaluation of diagnostic markers like intraepidermal nerve fiber density.

    • Main Results:

    • Dideoxynucleosides and immune mechanisms contribute to distal sensory polyneuropathy.
    • Intraepidermal nerve fiber density is a validated marker for neuropathy detection.
    • Mitochondrial toxicity is implicated in dideoxynucleoside-associated neuropathy.
    • Antiretroviral therapy can sometimes improve or reduce neuropathy frequency.

    Conclusions:

    • Enhanced surveillance for HIV-associated neuropathy enables earlier interventions.
    • Improved understanding of pathogenic mechanisms will lead to more effective treatments.
    • Current treatments focus on symptom reduction, necessitating further research into corrective therapies.