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Remission as the critical outcome of depression treatment
Michael E Thase1, Diane M E Sloan, Susan G Kornstein
1University of Pittsburgh Medical Center, Western Psychiatric Institute, Pittsburgh, Pennsylvania, USA.
Psychopharmacology Bulletin
|July 15, 2003
Abstract:
Major depressive disorder is currently the fourth largest contributor to the worldwide burden of disease. Direct and indirect costs associated with depression place a significant burden on the health care system and society. Despite the development of new antidepressant medications, the management of patients with depression remains a therapeutic challenge. Obtaining a response in antidepressant therapy-commonly defined in clinical trials as an improvement of >erotonergic and noradrenergic neurotransmission, will increase the likelihood of remission.