Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Onychomycosis in systemic lupus erythematosus: a case control study.

Alberto Tlacuilo-Parra1, Elizabeth Guevara-Gutierrez, Jorge Mayorga

  • 1Unidad de Investigación Médica en Epidemiología Clínica, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico. albtlacuilo@yahoo.com

The Journal of Rheumatology
|July 15, 2003
PubMed
Summary

Onychomycosis (fungal nail infection) is more common in systemic lupus erythematosus (SLE) patients. Trichophyton rubrum was the most frequent cause, with toenails most affected.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between <i>IL1B</i> rs16944 polymorphism and the risk of idiopathic inflammatory myopathies.

Frontiers in immunology·2026
Same author

Analysis of the impact of pharmacological treatment on arterial stiffness in patients with connective tissue diseases.

American heart journal plus : cardiology research and practice·2026
Same author

Cardiovascular risk scores, non-invasive vascular measures and myositis damage index reveal increased cardiovascular risk in idiopathic inflammatory myopathies: a case-control study.

BMC rheumatology·2026
Same author

Preliminary ultrastructural analysis suggests phenotype-specific myofiber alterations in idiopathic inflammatory myopathies.

Scientific reports·2026
Same author

Acquired Alopecias in Mexican Adults: A Clinical and Epidemiological Study of 1,888 Patients.

Cureus·2026
Same author

Adolescents Hospitalized for High Suicidal Risk: Effects of Short-Term Hospitalization on Quality of Life and Clinical Symptoms.

Indian journal of pediatrics·2026

Area of Science:

  • Dermatology
  • Mycology
  • Rheumatology

Background:

  • Immunosuppression in patients with systemic lupus erythematosus (SLE) increases susceptibility to fungal infections.
  • Onychomycosis, a common fungal nail infection, has not been extensively studied in SLE patients.
  • This study investigates the prevalence and characteristics of onychomycosis in SLE patients.

Purpose of the Study:

  • To determine the prevalence of onychomycosis in patients with SLE.
  • To describe the clinical presentations and causative organisms of onychomycosis in SLE patients.
  • To compare these findings with a control group.

Main Methods:

  • Fifty SLE patients and 50 age- and sex-matched controls were recruited.
  • Nail samples were collected from patients with abnormal nails exhibiting various clinical forms of onychomycosis.

Related Experiment Videos

  • Specimens underwent blinded mycological examination and culture.

    • Main Results:

    • Onychomycosis was confirmed in 24% of SLE patients, significantly higher than the 8% in controls (p=0.029).
    • Total dystrophic onychomycosis (TDO) was the most common clinical form (50%) in SLE patients.
    • Trichophyton rubrum was the predominant causative organism (50%) in SLE patients with confirmed infections.

    Conclusions:

    • Systemic lupus erythematosus patients exhibit a higher prevalence of onychomycosis compared to controls.
    • Trichophyton rubrum is the primary fungal pathogen responsible for onychomycosis in this SLE cohort.
    • Proximal subungual onychomycosis (PSO), a rare form in immunocompetent individuals, was exclusively observed in SLE patients.