[Wilms' tumor].

Area of Science:

• Pediatric oncology
• Pediatric nephrology
• Pediatric pathology

Context:

• Wilms' tumor is a common infant urinary tract cancer.
• Multidisciplinary management has significantly improved outcomes.
• Historical treatment protocols from SIOP and NWTSG are crucial.

Purpose:

• To review Wilms' tumor management.
• To summarize SIOP and NWTSG study findings.
• To highlight advances in pediatric oncology.

Summary:

• Wilms' tumor, a frequent infant urinary tract malignancy, has seen cure rates rise from 30% to 80%-95%.
• This improvement is due to combined surgical, oncological, and pathological management strategies.

Impact:

• Improved survival rates for pediatric cancer patients.
• Established evidence-based treatment guidelines for Wilms' tumor.
• Enhanced understanding of pediatric solid tumor management.