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Pregnancy and scleroderma.

A J Silman1

  • 1ARC Epidemiology Research Unit, University of Manchester, United Kingdom.

American Journal of Reproductive Immunology (New York, N.Y. : 1989)
|October 1, 1992
PubMed
Summary
This summary is machine-generated.

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Pregnancy in women with scleroderma (a rare autoimmune disease) rarely worsens the condition. However, scleroderma can lead to reduced fertility and increased risks of premature birth and low birth weight in infants.

Area of Science:

  • Rheumatology
  • Obstetrics & Gynecology
  • Autoimmune Diseases

Background:

  • Scleroderma disproportionately affects women, often diagnosed after pregnancy.
  • Pregnancy is a common experience for women before a scleroderma diagnosis.

Purpose of the Study:

  • To investigate the impact of pregnancy on scleroderma prognosis.
  • To determine if scleroderma affects fertility and pregnancy outcomes.
  • To explore the influence of reproductive history on scleroderma development.

Main Methods:

  • Review of case reports and series on scleroderma and pregnancy.
  • Analysis of epidemiological studies on scleroderma and reproductive health.
  • Examination of reproductive history in relation to disease onset and progression.

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Main Results:

  • Pregnancy rarely exacerbates scleroderma, though rare cases of renal crises are reported.
  • Scleroderma is associated with increased spontaneous miscarriage, prematurity, and low birth weight.
  • Reproductive history, including Raynaud's phenomenon, may precede diagnosis; fertility may be reduced.

Conclusions:

  • Pregnancy generally has a limited adverse effect on scleroderma prognosis.
  • Scleroderma poses risks to fertility and pregnancy outcomes, necessitating careful management.
  • Reproductive factors may offer insights into scleroderma's etiology and progression.