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Keloid in Iraqi patients: a clinicohistopathologic study
Khalifa E Sharquie1, Muhsin A Al-Dhalimi
1Department of Dermatology, College of Medicine, University of Baghdad, Baghdad, Iraq. sharquie@warkaa.net
Summary
This study investigated keloid characteristics in Iraqi patients, finding itching common and mast cells present in early lesions. Further research into keloid development and treatment is warranted.
Area of Science:
- Dermatology
- Pathology
Background:
- Keloid is a common benign fibrous overgrowth extending beyond the original defect.
- Frequently encountered in clinical practice, keloid presents unique challenges.
Purpose of the Study:
- To comprehensively evaluate the clinical and histopathologic features of keloid disease in the Iraqi population.
- To identify demographic and clinical patterns specific to keloid formation in this region.
Main Methods:
- Clinical assessment of 88 keloid patients.
- Histopathologic examination of 16 keloid specimens.
- Giemsa staining to identify mast cells in 8 patients.
Main Results:
- The disease predominantly affected individuals in their second and third decades (70.5%).
- Itching was a frequent symptom (52.2%), particularly in early lesions.
- Histopathology revealed hyperplastic epidermis, Grenz zone, telangiectasia, and pseudopodia extension; mast cells were found in 50% of early lesions.
Conclusions:
- Keloid exhibits distinct clinical and histopathologic features in the Iraqi population.
- Early lesions show increased mast cell presence, suggesting a role in keloid development.
- Further investigation into the pathogenesis and management of keloids is recommended.